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Glabrescione B
CAS No. 65893-94-9
Glabrescione B( GlaB )
Catalog No. M15505 CAS No. 65893-94-9
Glabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 598 | In Stock |
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| 25MG | 1224 | In Stock |
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| 50MG | 1674 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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Biological Information
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Product NameGlabrescione B
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NoteResearch use only, not for human use.
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Brief DescriptionGlabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction.
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DescriptionGlabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction, inhibits Hh signaling by impairing Gli1 function; inhibits the growth of Hedgehog-dependent tumor cells in vitro and in vivo, inhibits Gli1-dependent growth of cerebellum-derived normal progenitors; inhibits the growth of Gli-dependent medulloblastoma and tumor-derived stem-like cells; inhibits the growth of Gli-dependent basal cell carcinoma in vitro and in vivo.
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In VitroGlabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma.Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels. Cell Proliferation Assay Cell Line:ASZ001 BCC cells Concentration:5 μM Incubation Time:24-72 hours Result:Basal cell carcinoma cell proliferation was impaired.Western Blot Analysis Cell Line:ASZ001 BCC cells Concentration:1-10 μM Incubation Time:24-48 hours Result:Gli1 mRNA expression levels was decreased.
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In VivoAnimal Model:Female NOD/SCID mice (ASZ001 BCC allografts) Dosage:100 μmol/kg Administration:I.p.; every second day for 18 days Result:A significant reduction of tumor growth as well as Gli1 mRNA levels was observed.
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SynonymsGlaB
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PathwayWnt/Notch/Hedgehog
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TargetGli
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RecptorGli
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Research Area——
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Indication——
Chemical Information
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CAS Number65893-94-9
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Formula Weight450.531
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Molecular FormulaC27H30O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (221.97 mM)
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SMILES——
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Chemical Name3-[3,4-bis(3-methylbut-2-enoxy)phenyl]-5,7-dimethoxychromen-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Infante P, et al. EMBO J. 2015 Jan 13;34(2):200-17.
2. Ingallina C, et al. Nanomedicine (Lond). 2017 Apr;12(7):711-728.
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Glabrescione B
Glabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction.
